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The discovery by UC Davis wheat geneticist Jorge Dubcovsky and his team will help breeders more quickly develop varieties that can fend off the deadly pathogens and halt a worldwide wheat epidemic. The findings were recently published in the journal Proceedings of the National Academy of Sciences.
Wheat and stem rust have been in an evolutionary arms race for more than 10,000 years. In the 1950s, a major epidemic of the disease spread through North America and destroyed up to 40 percent of the wheat crop, the world’s second most important grain next to rice.
Since then, scientists have developed rust-resistant varieties to boost wheat’s immunity to stem rust. But the pathogens are making a comeback. A new strain of the stem rust — called Ug99 after it was discovered in Uganda in 1999 — is spreading throughout the region. About 90 percent of the wheat varieties grown worldwide are susceptible to Ug99.
“Ug99 has expanded to most of the wheat-growing regions in Africa and has crossed the Red Sea to Yemen and Iran,” said Dubcovsky, a professor with the UC Davis Department of Plant Sciences and a Howard Hughes Medical Institute investigator. “Ug99 is now at the door of the Punjab region — the bread basket of Asia — and identification and deployment of effective resistance genes are critical to mitigate this threat.”
Dubcovsky and his team identified three different resistance forms of Sr13, a gene from pasta wheat that is effective against Ug99 and another group of virulent stem-rust strains from Yemen and Ethiopia. In 2013, Dubcovsky and fellow researchers discovered another gene called Sr35 that also provides resistance to Ug99. The team is close to identifying a third gene that confers protection from the virulent strain.
Why genetics matter
To develop better varieties, breeders cross plants with desired traits and select the best offspring over multiple generations. Once stem-rust resistant genes have been identified, breeders can use molecular markers (specific regions of DNA) to select for the genes at the seed or seedling stage. This accelerates the crop-improvement process.
These molecular markers allow breeders to pyramid multiple stem-rust-resistant genes in the same plant to extend the durability of resistance.
“Wheat provides a substantial amount of calories and proteins consumed by humans,” Dubcovsky said. “We hope that a better understanding of the wheat-rust pathosystem will speed the development of new strategies to control this devastating pathogen.”
The research is supported by the Howard Hughes Medical Institute and funded with grants from the USDA, the USDA National Institute of Food and Agriculture, and the USDA Agricultural Research Service.
2017 UC Davis Innovator of the Year: Jorge Dubcovsky
Dubcovsky's recent innovation has greatly accelerated the study of gene function in wheat. His laboratory developed a gene capture tool and used it to sequence most wheat genes in a collection of 2,700 mutant lines.
University of California - Davis , November 16, 2017